How NAD+ Affects The Energy Metabolism

The body relies on a symbiotic set of processes for optimal health. When all systems are working together, the body runs smoothly. When they do not, chronic health issues can arise, such as fatigue and inflammation.

The metabolism is the system that converts nutrients from food into energy, and it relies heavily on NAD+ to help it function properly. NAD+ helps by activating sirtuins, which are proteins that contribute to the regulation of cellular health. It also assists with metabolic function by encouraging mitochondrial fitness and essentially rewiring the metabolism to function as it should. But what is NAD+, exactly? Let’s find out more about this compound and how NAD+ affects the energy metabolism.

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Image by Jaron Nix on Unsplash: NAD+ is a coenzyme molecule that is required for many processes within the body.

What is NAD+?

Nicotinamide adenine dinucleotide (NAD+) is a chemical compound within the body that works to support the health of cells. It is classified as a dinucleotide because it consists of two nucleotides joined through phosphate groups, with one containing an adenine base while the other contains nicotinamide.

Vitamin B3 is considered to be a precursor to NAD+. When the vitamin is converted into NAD+ it contributes to the process of converting food into energy, repairing DNA, strengthening cell defense, and regulating circadian rhythm. It is not difficult to get enough vitamin B3 for NAD+ biosynthesis, and it’s been found that less than 20 mg of niacin per day is enough to keep up with the body’s demand.

In people with deficiencies of vitamin B3, NAD+ levels can suffer. However, there are a few other substrates for NAD+ pathways that can help stimulate synthesis, including the amino acid tryptophan, nicotinamide riboside, and nicotinamide mononucleotide.

While the body ages, levels of NAD+ decline, thus making a person more susceptible to age-related conditions and other health issues that can arise when the metabolism isn’t at its best. Some conditions that have been linked to declining levels of NAD+ in the body include heart disease, diabetes, and Alzheimer’s disease.

Why is NAD+ so important?

Cells need both hydrogen and electrons to produce and store energy. NAD+ is the molecule that carries electrons and hydrogen to the cells so that the process of creating energy can continue through its reduced form known as NADH. NADH is the molecule that takes electrons from NAD+ and then gives them to other cells so that they can perform cellular processes. Without NAD+ and other electron carriers within the body, the cells would not be able to produce and store the energy, leading to fatigue on a cellular level.

In terms of other cellular processes such as DNA damage repair, NAD+ is needed to help restore healthy levels of DNA. If the body becomes depleted of NAD+, as it does with age, DNA cannot be repaired as it should be. It can also become depleted in cases of obesity or if the body is not receiving the required nutrients it needs. Metabolic disorders such as fatty liver disease and diabetes have been closely linked with depleted levels of NAD+. The good news is that if a person receives precursors of NAD+, optimal levels can be restored, which could help prevent metabolic diseases.

What is the role of NAD+ in metabolism?

NAD+ plays a vital role in oxidation reactions that contribute to metabolism. It is a contributing part of several different metabolism pathways, such as breaking down glucose for energy, oxidizing nutrients for optimal energy release, and the breakdown of fatty acids to produce energy. The energy metabolism is greatly affected by these processes, as it needs them to occur to help distribute energy throughout the entire body.

How do you raise your NAD+ levels?

The best way to ensure that you have optimal levels of NAD+ is by ingesting one of the precursors to aid in synthetization. Perhaps one of the most common nutritional supplements to take to help encourage NAD+ production is vitamin B3.

Human trials have found that increasing intake of vitamin B3 led to increased levels of NAD+ in muscles by three times the amount prior to taking the vitamin. Getting B3 through diet is the best way to utilize it as a NAD+ precursor; it can be found in high amounts in fish, peanuts, and avocados.

Some research has also shown that getting more exercise can increase levels of NAD+. This is because when the body uses more energy, it needs to create more. However, it should be noted that if there is not enough of a NAD+ precursor in the body to aid in the production of the molecule, exercising may not help to increase levels.

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Image by Estudio Bloom on Unsplash: Avocados contain high levels of vitamin B3, which is needed to help synthesize NAD+, so eating more could help boost energy levels.

Does NAD+ give you energy?

Since NAD+ is a vital component to energy levels, it can be said that it helps the body create energy. The molecule itself doesn’t necessarily give you energy, though. It is needed for cellular processes that encourage the metabolism to function as it should, thus dispersing energy throughout the body.

Synapsins are proteins that help maintain healthy levels of NAD+, and thus are important for overall energy production. Vital RX’s Fitness and Energy Subscription boxes contain synapsin so that stores of NAD+ are kept at their most optimal, leading to an overall healthy level of energy and metabolic function. NAD+ is a key player in energy production, and keeping levels up can be as easy as adding a few things to your diet and supplementing with the right products.

Featured image by Aditya Saxena on Unsplash

What’s Included In Our Energy Subscription Box (And Why)

Having low energy levels or suffering from chronic fatigue can make even life’s basic tasks that much more difficult. In today’s fast-paced society, many people find it difficult to stick to a diet and exercise routine that provides them with the optimal amount of nutrients and movement to keep their energy levels where they need to be. Pair that with a lack of sleep due to demanding lifestyles at home and work, and energy levels become even more depleted.

But aside from the aforementioned diet, exercise, and sleep routines, there are a few more ways to boost energy levels. One such way is through an energy subscription box, like the one offered by Vital RX, which contains high-quality ingredients designed to give your body that extra boost it needs to keep up with all of life’s demands.

Why is my energy so low?

People can suffer from low energy for a plethora of reasons, and no two people are alike when it comes to why they’re suffering from chronic fatigue. Possible reasons you may be tired all the time include:

A diet full of refined carbs

Carbohydrates generally give you energy to use throughout the day because the body breaks them down and turns them into sugar as an energy source. When you fill up too much on these foods, though, it can backfire. This is because carbs can lead to a spike in blood sugar levels, and when that happens, your body works in overdrive to produce more insulin to help rid the body of the excess sugar. Research has shown that limiting refined carbs has a direct connection to increased energy levels.

You aren’t moving enough

For those suffering from CFS, getting up to exercise could be a daunting task, but it could actually be the reason for your extra tiredness throughout the day. Exercising can help to reduce overall fatigue levels among both healthy people and those suffering from chronic or terminal illnesses.

Your sleep is off

Not getting enough sleep can cause tiredness, but high-quality sleep is more important than the number of hours you spend in bed. Research found that if you get seven hours of uninterrupted sleep per night, your body is able to go through the five stages of the sleep cycle, leading to less fatigue overall.

You’re thirsty

The body needs water to function, and if it is dehydrated, it’s likely that you’ll suffer from low energy levels. While you move throughout the day, you lose fluid that needs to be replenished to keep energy levels up.

Other chronic illnesses can also lead to fatigue and low energy levels, such as autoimmune disorders, viral infections, mental illness, and hormone imbalances.

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Image by Michele Blackwell on Unsplash: Taking supplements for chronic fatigue can help restore balance to the body and return high energy levels when they’re depleted.

How to boost energy

There are ways to naturally boost energy levels if you feel as though chronic fatigue has taken a hold of your life. Although some may be harder to accomplish than others, when used in conjunction with diet, exercise, sleep, and supplementation, they can go a long way to restore how energized you are to take on your day.

Stress is a huge energy zapper, and it can lead to a host of other health problems that will deplete your energy even further. When the body is undergoing too much stress, it releases cortisol. The hormone is generally responsible for the regulation of the stress response, but in high levels, it can lead to chronic fatigue syndrome. CFS causes the body to become tired and weak; patients often experience sleep disturbances, which advances the condition even further.

Managing stress levels if a great way to avoid CFS and increase energy levels naturally. Other ways to help keep you energized include:

  • Lightening your workload where possible.
  • Avoiding negative health triggers such as smoking and alcohol consumption.
  • Eating foods with a low glycemic index.
  • Staying hydrated.

Following the above steps along with supplementation can increase energy levels and help rid the body of chronic fatigue.

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Image by Zhang Kaiyv on Unsplash: Getting high-quality sleep is one of the most important factors when it comes to keeping up energy levels.

What is the best supplement for energy?

There is no one supplement that reigns supreme when it comes to boosting energy levels, but there are a few that, when put together, can work wonders. For example, ashwagandha has shown to increase energy by offering further resilience to stress levels. In the case of mental fatigue, the herb rhodiola was found to have a positive effect when people were taking it regularly.

Other natural herbs and supplements that can be taken to help combat low energy levels include:


This coenzyme is found naturally in the body and is used by cells to create energy while protecting systems from oxidative stress. Without adequate levels of CoQ10, the body has a hard time producing energy to stay healthy, thus leading to extreme tiredness.


Many people, especially women, may suffer from low levels of iron. Iron assists in the way oxygen is transported throughout the body by creating hemoglobin. When levels are low, red blood cells have a harder time carrying oxygen, which leads to tiredness and chronic fatigue.

Beetroot powder

Beetroot powder contains nitrate, which assists in the production of oxide, increasing blood flow and thus giving your body a better chance at producing energy.

Vital RX Energy Subscription Box

The above are just a few examples of supplements that can help battle chronic fatigue. Vital RX’s energy boost supplement box contains other vital nutrients that can play a pivotal role in combating chronic fatigue and overall tiredness. Let’s take a look at some of the box’s ingredients.

MIC Combo Blend

Lipotropic injections contain high levels of vitamins and nutrients that can help battle chronic fatigue. They often contain Vitamin B12, methionine, inositol, and choline. When taken regularly, this can help maintain energy levels.


NAD is crucial when it comes to regulating cell metabolism. Synapsin helps to maintain healthy levels of NAD in human cells, acting as a protector when it comes to neurological effects and chronic stress. Since chronic stress often leads to chronic fatigue, the addition of synapsin can help mitigate the body’s responses, leading to more energy overall.  


DHEA is a hormone precursor in the human body and is a source of sex hormones. Studies have shown that when administered to patients with chronic fatigue syndrome, DHEA can reduce the symptoms significantly, restoring overall energy levels.


This active nonpeptide plays a crucial role in bone health, but can also help increase energy levels by improving sleep quality and cognitive function. 

Featured image by Jordan Opel on Unsplash